Utilization of Mentzer Index to Discriminate Between Beta Thalassemia Minor and Anemia of Iron Deficiency, Followed by HPLC

Objective: Aim was to evaluate the sensitivity and specificity of Mentzer index in differentiating beta thalassemia minor from anemia Iron deficiency. Materials Methods: A cross-sectional study conducted Hematology unit Hayatabad Medical Complex .Sampling done non-consecutively. total 860 cases with value Hemoglobin less than 11 Gm/DL were counted. In all selected full blood count checked Index mean corpuscular volume [MCV] per RBCs )was calculated. Value <13 suggests diagnosis β Thalassemia minor/trait while more 13 is indicative deficiency (IDA). Confirmation diagnoses made by hemoglobin using HPLC. Values for calculated two differentials microcytic hypochromic presenting microcytosis hypochromia. Results: Mean level patients 9.01±1.85. Minimum maximum 2.90 g/dl. RCB 4.66±4.59 minimum 1.07 136. MCV 63.89±9.01. 39.40 92.10 respectively. Men 15.70±7.68. 7.80 10.7 Based on criteria 489(56.86%) had iron 371(43.14%) higher suspicion thalassemia. Conclusion: It concluded that differentiation among Beta , can be beneficial discriminate a high as well percentage thus through cost effective way, only suspected trait/minor further confirmed Hb Electrophoreses. Keywords: Index, Anemia,